|Title:||Assistant Professor of Biology
|Office:||312 E Main Building|
Megan Lindsay Povelones received her B.S. in Biology from Loyola University Maryland in 2002 and her Ph.D. in Cellular and Molecular Medicine at Johns Hopkins University School of Medicine in 2008. She then performed postdoctoral work in the United Kingdom, first at the University of Oxford and then at Imperial College London. Her research interests include single-celled parasitic organisms, including the human pathogen Trypanosoma brucei, which is the causative agent of African sleeping sickness. This devastating disease has an unusually high mortality rate, and affects tens of thousands of people in sub-Saharan Africa. In addition, these fascinating parasites have many unique biological properties, including the structure and function of their mitochondrion and the unusual arrangement of their mitochondrial genome.
Clayton, A.M.*, Guler, J. L.*, Povelones, M. L.*, Gluenz, E., Gull, K. Smith, T.K., Jensen, R.E., Englund, P. T. (2011) Depletion of mitochondrial acyl carrier protein in bloodstream form Trypanosoma brucei causes a kinetoplast segregation defect. Eukaryotic Cell, 10 (3), 286-92 *co-first authors.
Gluenz, E.*, Povelones, M. L.*, Englund, P. T., Gull, K. (2011) The kinetoplast duplication cycle in Trypanosoma brucei is orchestrated by cytoskeleton-mediated cell morphogenesis. Molecular and Cellular Biology, 31 (5), 1012-21 *co-first authors
Liu, B., Wang, J., Yaffe, N., Lindsay, M.E., Zhao, Z., Zick, A., Shlomai, J., Englund, P.T. (2009) Trypanosomes have six mitochondrial DNA helicases with one controlling kinetoplast maxicircle replication. Molecular Cell, 35 (4), 490-501.
Lindsay, M.E.*, Gluenz, E.*, Gull, K., Englund, P.T. (2008) A new function of Trypanosoma brucei mitochondrial topoisomerase II is to maintain kinetoplast DNA network topology. Molecular Microbiology, 70 (6), 1465-76 *co-first authors
Li, Z., Lindsay, M.E., Motyka, S.A., Englund, P.T., Wang, C.C., (2008) Identification of a bacterial-like HslVU protease in the mitochondria of Trypanosoma brucei and its role in mitochondrial DNA replication. PLoS Pathogens, 4 (4): e1000048
Zhao, Z., Lindsay, M.E., Roy Chowdhury, A., Robinson, D.R., Englund, P.T., (2008) p166, a link between the trypanosome mitochondrial DNA and flagellum, mediates genome segregation, EMBO Journal, 27 (1), 143-54.